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KMID : 0385520100230020119
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Analytical Science & Technology
2010 Volume.23 No. 2 p.119 ~ p.127
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Simultaneous analysis of β-lactam antibiotics in surface water
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Huh Min-Jung
Myung Seung-Woon
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Abstract
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An effective method for the simultaneous analysis of β-lactams from surface water was established. After solid-phase extraction with HLB (Hydrophilic Lipohilic Balance) cartridge at pH 2, seven β-lactams (amoxicillin, ampicillin, penicillin G, cefaclor, cefadroxil, cefatrizine and cephradine) were determined using LC/ESI-MS/MS. In this newly established method, correlation coefficients (r²) of calibration curves for seven β-lactams in blank surface water appeared to be 0.9911~0.9995 in the concentration range of 0.01~1.0 ng/mL. The limits of detection (LODs) and the limits of quantificaiton (LOQs) in spiked surface water were shown to be 0.0003~0.0234 ng/mL and 0.0046~0.0778 ng/mL, respectively. The developed method is believed to serve as a rapid and reliable method for the qualitative and quantitative analysis of residual β-lactam antibiotics from aquatic environment.
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KEYWORD
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β-lactam, surface water, LC/MS/MS, residual analysis
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